Take ramp right for I-5 North toward Seattle.  At exit 165, take ramp left and follow signs for Seneca St.  Bear left onto Seneca St.  Turn right onto 4th Ave and arrive at 2101 4th Ave.

From North:

Take I-5 South. At exit 165B, take ramp right and follow signs for Union St. Keep straight onto Union St. Turn right onto 4th Ave and arrive at 2101 4th Ave.

From East:

Take I-90 toward Seattle / Mercer Island. At exit 2C, take ramp right for 7th Ave toward Madison St. Convention Place.  Turn left onto Madison St.  Turn right onto 4th Ave.